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Additionally, GLP-1 and its sister peptide GLP-2 both play roles in maintaining intestinal barrier integrity

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Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis

Heartburn Rare, but serious side effects may include: Acute pancreatitis (including fatal, hemorrhagic, necrotizing) Acute gallbladder disease Acute kidney injury (typically secondary to dehydration) Severe gastrointestinal disease / delayed gastric emptying Hypoglycemia (especially with insulin or sulfonylureas) Hypersensitivity reactions including anaphylaxis and angioedema Pulmonary aspiration during anesthesia or deep sedation (delayed gastric emptying) Suicidal behavior and ideation (monitor) Diabetic retinopathy complications (in T2D clients with pre-existing retinopathy) Thyroid C-cell tumors (rodent data)