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one animal died after being given a first dose of vehicle, that animal was replaced by one of the backup monkeys for which we had baseline data

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Estrogens play an important role in a larger number of physiological processes, including the development of the female reproductive system, regulation of the menstrual cycle, the development of female secondary sex characteristics such as increased adipose tissue and the development of breast tissue, and the maintenance of pregnancy

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doi:10.11124/jbisrir-2015-1987 [3] Piantanida E, Ippolito S, Gallo D, et al