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The increase in lactate that we detected points towards a defect in oxidative energy metabolism, but this conclusion must be treated cautiously given the difficulty of measuring lactate in the presence of the much larger and broader macromolecule (MM) resonance at ~1.35 ppm, with the lactate signal being a small shoulder on that peak (Fig

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Persistent oxidative stress and induction of nuclear-factor-erythroid 2related-factor 2 (NRF2) antioxidant response in KO livers EtOH feeding decreased GSH levels specifically in the mitochondrial pool of livers of WT mice (Fig

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