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Trends in Molecular Medicine

These medications carry a boxed warning about thyroid C-cell tumors (contraindicated with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings about potential risks including pancreatitis, gallbladder disease, acute kidney injury with dehydration, and worsening diabetic retinopathy with rapid glucose reduction (particularly with semaglutide)

We found similar alterations in the probability of cellcell communication events between C35 GABA4 and C35 Glut10 sender neurons and hypothalamic receiver neurons after treatment with acyl-GLP-1 or the GIPR antagonist compared with vehicle DIO controls, which clearly diverge from that of acyl-GIP (Fig

2022, Frontiers in Pharmacology )

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