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Furthermore, our safety analysis was limited to gastrointestinal AEs and serious AEs, as other off-target effects such as hypoglycaemia, pancreatitis or cardiovascular events were either not uniformly reported or not quantified across the included studies

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Consumers can now directly buy the product without a prescription in what the Trump administration says is a significant step to address the opioid crisis

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However, combining these two medications is not without challenges