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Although 1 mM metformin demonstrates a greater modulatory effect on HG-HL-induced apoptosis than either 10 nM semaglutide or 10 nM tirzepatide, the combinations of semaglutide or tirzepatide with metformin achieve a similar level of apoptosis mitigation as 1 mM metformin, suggesting the absence of any potentiation or additive effects

Calcium activates proteases that convert XDH to XO, disrupts mitochondrial function leading to increased electron leakage, and can activate other ROS-producing enzymes (Huang et al., 2020)

Zhao S, Blum JA, Ma F et al (2022) Anthocyanin accumulation provides protection against high light stress while reducing photosynthesis in apple leaves

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