NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure
Keremi, B., Lohinai, Z., Komlosi, K., Pinter, E., Gyires, K., Szekely, A
It is determined by a qualified healthcare professional based on factors such as nutrient deficiencies, health goals, and response to treatment
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Thus, in both folate and vitamin B 12 deficiencies, folate is unavailable to participate in DNA synthesis