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In the current subgroup analysis of PIONEER 4, which included relatively few patients receiving both treatments, reductions in HbA 1c (of 1.11.2%) and body weight (5 kg) were similar after 1 year in patients with T2D treated with oral semaglutide with or without background SGLT2i

The researchers concluded that PD-L1 status should not be used to select patients for treatment with pembrolizumab, as both groups benefited from adjuvant pembrolizumab

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