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doi: 10.1056/NEJMoa2206038 47 WillardFSDourosJDGabeMBShowalterADWainscottDBSuterTMet al

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The core of our discussion presents a deep dive into an expanded mechanistic tapestry, where we integrate classical pathways with cutting-edge discoveries in epigenetics (e.g., protein arginine methyltransferase 5 (PRMT5) inhibition), cell death (ferroptosis), and immunomodulation

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