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OLeary NA, Wright MW, Brister JR et al (2016) Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation

Currently, therapies rely largely on pharmacological agents that curb inflammation by targeting immunoregulatory pathways, including Janus Kinase (JAK) inhibitors and other intracellular tyrosine kinases [5, 6]

Co-administration of mesna, which could influence distribution by ion-pairing, did not alter the pharmacokinetics

It sits at the intersection of neuroprotection, neurorecovery, and cognitive enhancement, with data supporting applications across that entire spectrum

It just makes the process miserable and increases the risk of discontinuation