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Monitor for Unusual Symptoms: Report any unexpected changes in mood, behavior, or physical health (e.g., extreme fatigue, chest pain, shortness of breath)

Heartburn: Both medications can contribute to acid reflux or heartburn, especially during the first few weeks of treatment or after a dose increase

Contact your GP or healthcare provider for assessment to exclude other causes such as inflammatory arthritis or injury

Besides c-Met inhibitors, many new therapeutic strategies have been developed, such as the use of miRNAs to regulate HGF/c-Met signaling pathways to inhibit liver cancer progression, targeting endocytosis and more downstream molecules, Hic-5 as a therapeutic strategy to reduce side effects of c-Met inhibitors, as well as herbal treatments

Ann Intern Med 122 : 5459 LeRoith D, Roberts Jr CT (2003) The insulin-like growth factor systems and cancer