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GIPRs have been localized to human pancreatic -cells, and intravenous GIP infusion activates GIPR and intracellular signaling in pancreatic -cells, augmenting glucagonotropic effects in hypoglycemic conditions in humans (130)
GLP-1 therapy offers a medically guided solution that addresses underlying causes, not just surface symptoms
If a patient had both obesity and type 2 diabetes, their GLP-1 prescription might still be covered under the diabetes diagnosis, though many plans implemented stricter documentation requirements to verify the primary treatment purpose
Both are manageable
Most patients are piggybacking these medications through their insurance by receiving them under FDA-approved uses, or by paying out of pocket with manufacturer discounts
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