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Although stress hormones do not represent the first pathogenetic markers for vitiligo manifestations, levels of cortisol and dehydroepiandrosterone (DHEAS) and their ratio (+cortisol/DHEAS) are related to vitiligo severity and increase the prevalence of psychiatric issues

Together, these data, most of which do not stem from GLP-1 RA specific research, suggest that beyond biological rebound, integrating body image work, stress regulation, and support for reconstructing identity and agency may be relevant to long-term maintenance

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