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Generally, GSH binding shows relatively strong affinity to the G-site (near the active cysteine residue) and weak affinity to the H-site in the case of WT proteins

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Most standard oral supplements and food-based sources deliver only a fraction of their total glutathione to the cells

However, as mentioned before these antioxidants have a very short half-life and are only effective after mild bouts of oxidative stress

Using SFN in combination with artemisinin presents a novel and promising strategy to tackle artemisinin resistance