A key extrinsic pathway component is the death receptor Fas (CD95), which, upon binding to Fas ligand (FasL/CD95L), recruits the adaptor protein FADD (Fas-associated death domain protein) and procaspase-8 to form the death-inducing signaling complex (DISC)
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The metabolodiuretic promise of sodium-dependent glucose cotransporter 2 inhibition: the search for the sweet spot in heart failure
doi: 10.1007/s11255-019-02329-5 76