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471 The mechanisms by which SGLT2 inhibitors treat heart failure include lowering blood glucose levels by inhibiting the SGLT2 protein in the renal tubules and reducing glucose reabsorption in the tubules

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Results at 68 weeks: 40.4% of CagriSema participants lost 25% or more of their body weight 91.9% lost at least 5% Blood pressure fell by 10.9 mmHg systolic on average About 40% of participants reduced or stopped blood pressure medications 87.7% of those with prediabetes at baseline achieved normal blood sugar Results were published in the New England Journal of Medicine and presented at the American Diabetes Associations 2026 Scientific Sessions

Dec 29, 2025 CagriSema represents the next evolution in medical weight loss - Novo Nordisk's branded combination of semaglutide 2.4mg and cagrilintide 2.4mg that produced 15-25% body weight loss in Phase 3 trials