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The SUSTAIN and SELECT trials documented heart attack, stroke, and cardiovascular death rates that were either equal to or lower in semaglutide groups compared to placebo

Retrieved from Pinto, M., Brennan, L., Diehl, K., et al

Further, alogliptin augmented the PGC-1/NRF1/TFAM signaling and enhanced mitochondrial biogenesis [30]

Although it has been reported that the risk of EWDR is increased by faster or more effective lowering of HbA 1c in individuals treated with insulin or a sulfonylurea [14, 25], in our study reduction in HbA 1c was not independently associated with increased odds of the PDR endpoint

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