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However, due to lifestyle factors such as limited sun exposure and dietary insufficiencies, many individuals experience Vitamin D deficiency, which can manifest as fatigue, depression, and weakened immune response

Finally, our group identified STAT3 that associates with JAK and mediates IL-6 and IL-23 signaling, as a potential therapeutic target in SLE (60, 61)

For included participants, after hemodynamic resuscitation and stabilization, nutritional support with enteral tube feeding (25 kcal/kg of energy) was begun

Furthermore, because S-A-GSH easily crosses the blood-brain barrier, it provides direct neuroprotection, reducing the neuroinflammation that drives cognitive impairment

Chronic depletion of these essential nutrients such as vitamin C , lysine, and proline in the endothelial and vascular smooth muscle cells impairs their ability to function properly