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Administering metformin as a treatment for adolescent PCOS, particularly during late childhood and early adolescence, has shown promising results in improving abdominal and hepatic fat metabolism

In addition, it is notable that phase I studies of BSO administered with the anticancer drug melphalan demonstrated that continuous infusion of BSO was relatively non-toxic and resulted in depletion of tumor GSH (16,17)

10.1007/s00299-015-1912-8 Plant Cell Rep

In addition, melatonin inhibits the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) 75 and limits the production of excessive amounts of prostanoids and leukotrienes and nitric oxide (NO), as well as other mediators of the inflammatory process, such as chemokines and adhesion molecules 73,76 (Fig

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