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Microdosing GLP-1 drugs, the class of obesity and diabetes medications that includes Ozempic, Wegovy, Mounjaro, and Zepbound, has emerged as a weight loss trend

The Investigators were not blinded to allocation during experiments and outcome assessment, besides measurements of max cristae width which were performed in a blinded fashion to prevent biased outcomes

SIM1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

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P53-dependent glutamine usage determines susceptibility to oxidative stress in radioresistant head and neck cancer cells