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GLP-1, the endogenous agonist of GLP-1R, is predominantly synthesized in enteroendocrine cells of the distal small intestine and secreted in the blood when food enters the duodenum [4, 5]

In the SURMOUNT-1 clinical trial, patients taking the highest dose (15 mg) of tirzepatide lost about 21% of their body weight over 72 weeks

Individuals with diabetic ketoacidosis or those in a hyperosmolar hyperglycaemic state require immediate medical intervention rather than weight management treatment

If you are already experiencing symptoms at the starting dose, increasing will make them worse

Surveillance Imaging and Alpha Fetoprotein for Early Detection of Hepatocellular Carcinoma in Patients With Cirrhosis: A Meta-analysis