Both lightly and darkly pigmented skin contain similar numbers of melanocytes, [12] with difference in skin color due to differences the packing of eumelanin into the melanosomes of keratinocytes: those in dark-toned skin are "packaged into peri-nuclear distributed, ellipsoid" melanosomes while those light-tone skin are "assembled into clustered small, circular melanosomes"
[DOI] [PMC free article] [PubMed] [Google Scholar] [30].VanderVeen BN, Cardaci TD, Unger CA, NeSmith MM, Freeman JC, Bastian AV, et al
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Increased behavioral responses to ethanol in Lmo3 knockout mice
The timeline varies by medication, dose, and individual tolerance