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It also leads to an increase in anti-inflammatory mediators such as IL-4 (116, 117)

Such a Se-utilization hierarchy amongst selenoproteins and body compartments is related to the sophisticated regulation of selenoprotein expression (Papp et al., 2007

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A 2025 meta-analysis (a study that pools data from multiple trials to find patterns) confirmed this ranking, with retatrutide showing a mean difference of -16.34 kg vs tirzepatide's -11.82 kg vs placebo (J Endocrine Soc, 2025)