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Abstract Background: Suicide risk is prominent among the problems affecting populations, mainly due to the broad family, psychosocial and economic impact
But because of the need to fast and draw blood several times, it is not as suitable for repeated use as a screening tool
The title for Figure 4 should be reconsidered as the term "mutually opposite signal modulation" is unclear and/or does not reflect the description to follow. Response: We have replaced the term mutually opposite signal modulation with: amplification of MC3R signaling and attenuation of GHSR1a signaling For Figure 5, the figure legend should clarified if 5-HT2c-GHSR1a dimerization produces reduced Ca++ accumulation with (as appears to be implied by the figure) or without ligand for each receptor. Response: To make it clearer that the 5-HT2C ligand is not required, while the ghrelin ligand is, we have changed the description to read: When dimerized with 5-HT2C, GHSR1a displays a 65% reduction in ghrelin-induced Ca2+ accumulation, with this effect not requiring the presence of a 5-HT2C ligand. Reviewer #2: The review includes an excellent explanation of GSHR1a dimerization with other receptors at the cellular and molecular level and also does a good job of explaining technical aspects of this type of work
The sponge is now much lighter, but the sponge itselfits structure, its material, its sizehasn't changed at all
An indirect evaluation can be made by measuring the levels of vitamin K-dependent coagulation factors, which are below 50% in the presence of vitamin deficiency
