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(PubMed) Dermatologist-recommended skin-lightening treatments ( chemical peels , laser toning , topical agents) these have established safety and efficacy profiles (when done properly) compared to unproven injections

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and (4) metformin is safe, well-tolerated and cost-effective, making it an attractive addition to a cytotoxic therapeutic regimen, and it can be administered orally alongside infusional 5FU

The indirect mechanisms consist of modulating gene expression and intracellular signaling pathways, promoting the activation and synthesis of endogenous antioxidant enzymes [38]

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