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According to the FDA-approved prescribing information, patients start at 0.25 mg once weekly for the first four weeks (a dose-initiation phase not intended for blood sugar control), then increase to therapeutic doses

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The inflammatory response can activate the UPR through three major signaling pathways (PERK, ATF-6 and IRE1)

Thyroid cancer risk, identified in animal studies at high doses, remains a theoretical but serious concern