What foods should I avoid in my first week on GLP-1
This convenient schedule makes adherence easier compared to daily dosing, with consistent therapeutic effects throughout the week supporting continuous blood glucose regulation and weight management
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
You will need to show up for clinic visits regularly, sometimes for over a year
The weight tends to come back because: When weight returns, your blood pressure and cholesterol levels increase, too, which raises your risk for cardiovascular disease and other complications