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In addition, the nanoprotein hydrolytic targeted chimera (PROTAC) formulation ARV@PEG-ICG composed of indocyanine green-functionalized polyethylene glycol (PEG-ICG) phototherapeutic agent and BRD4 degrader ARV-825, rapidly decomposes under activation in the acidic tumor microenvironment thereby inducing ICD, promoting DCs maturation and T cells activation and inhibiting tumor growth (208)

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The activation of the NLRP3 inflammasome further exacerbates inflammatory injury (Ning et al., 2020)