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Additionally, one clinical study reported that consumption of chlorogenic acid-enriched coffee not only improved plasma antioxidant capacity and decreased plasma lipid and protein oxidation but also donated to enhancing cardiovascular health in people with hypercholesterolemia [169]

Br J Clin Pharmacol 2025 demonstrates that co-infusing a GLP-1 agonist with glucagon produces a perfectly additive HR response (+4 bpm + +4 bpm = +7 bpm at 60 min in n=12 lean males), confirming that glucagon drives chronotropy via a parallel pathway independent of GLP-1R cross-reactivity

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For apoptosis detection, the DAB (SA-HRP) TUNEL Cell Apoptosis Detection Kit (G1507-50T, Servicebio) was used to stain paraffin-embedded sections

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