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Hence, the number of ATP is reduced in every reaction, synthesis of -GC can act as a rate-limiting factor for GSH synthesis, and the -ECS activity depends on Cys-availability

In addition, elevated TMAO levels are closely associated with an increased risk of cardiovascular disease in CKD patients, possibly due to TMAO enhancing platelet reactivity and amplifying endothelial inflammatory responses, thereby increasing the risk of thrombosis

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