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As the majority of L-cells are located in the distal ileum and colon, the early phase release is likely to be explained by intramural autonomous neural signaling, gut peptides, or neurotransmitters [74, 75], although the small population of L-cells located in the proximal jejunum may be sufficient to account for the early phase secretion through direct contact with luminal nutrients [76]

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A 12-week study by Abdulghani et al

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