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Discuss with your provider whether the additional weight loss justifies the higher dose, or whether maintaining at the plateau weight with the current dose is the more appropriate goal

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If you have type 2 diabetes or non-diabetic hyperglycaemia (prediabetes) and are on combination therapy, an inadvertently shortened dosing interval might increase the risk of hypoglycaemia

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While tirzepatide has yet to demonstrate direct cardiovascular risk outcomes in patients without type 2 diabetes, tirzepatide-treated groups did demonstrate reductions in cardiometabolic variables resulting in a significantly lower 10-year predicted ASCVD risk in patients with overweight or obesity without type 2 diabetes in post hoc analysis of the SURMOUNT-1 trial [49]