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doi: 10.1016/j.ccr.2007.05.008 33 DurnRVHallMN

Study Design This 12-week open-label pilot study was conducted to investigate the efficacy of glutathione use as a supplement for the symptomatic treatment of irritability and aggression in children with ASD, as defined by criteria set forth in the DSM-5

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While mPFC Glu levels remained unaffected, the GABA signal was significantly reduced in THC exposed animals, suggesting lower inhibitory drive in the mPFC network and a strong increase of EPSC frequency consistent with previous findings [4, 5]