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When injected once weekly, semaglutide binds to GLP-1 receptors in the brain's satiety centers, reducing hunger signals and increasing feelings of fullness

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Next, avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated

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Study OA-1: Two hundred fifty-six patients (N=128 on CYMBALTA, N=128 on placebo) enrolled and 204 (80%) completed the trial

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