The tolerability profile is generally favorable, with most patients experiencing manageable side effects
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Prodromal symptoms were reported by 56.1% of patients prior to attacks, being most frequent erythema marginatum (38.7% of patients), and 84.7% could identify an attack trigger: 66.9% cited stress, 56.2% trauma, 36.2% infections, 27.5% menstruation, 15.6% pregnancy, 9.4% exogenous oestrogens, and 22.5% other factors
At standard doses (250 to 1000mg daily), side effects are uncommon