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Additionally, the coordinated control of glycolysis and gluconeogenesis in the liver is adjusted by the phosphorylation state of the enzymes that catalyze the formation of a potent activator of glycolysis called fructose 2,6-bisphosphate

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This combination enhances its ability to regulate metabolism by activating two hormone receptors instead of one, potentially leading to more effective treatment outcomes

Furmark gratefully acknowledges support by research grants from the Swedish Brain Foundation (FO2016-0106 and FO2018-0255), the Swedish Research Council (2016-0228), and Riksbankens Jubileumsfondthe Swedish Foundation for Humanities and Social Sciences (2017-0639:1)