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Ethics statement The animal study was approved by Institutional Animal Care and Use Committee at the School of Medicine and Public Health of the University of Wisconsin-Madison

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Intracerebral hemorrhage injury mainly results from the secondary injury followed hematoma formation including hemoglobin cytotoxicity and explosive inflammatory response, which mainly resulted in brain edema and neuron death (Shi et al., 2012

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doi:10.1016/j.eururo.2013.01.008