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Relationship between baseline CAN and eGFR and UACR changes was assessed by multi-nominal logistic regression adjusted for baseline age, HbA1c, ACEi/ARBs use, retinopathy status, blood pressure, history of coronary artery disease and hypertension

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The analysis integrated findings from the CANVAS and CREDENCE trials ( n = 14,543) for SGLT2i (203), a meta-analysis of eight cardiovascular outcome trials for GLP-1 RAs ( n = 60,080) (204), and the FIDELIO-DKD and FIGARO-DKD studies for finerenone ( n = 13,026) (179)

View correction Figures Abstract Class B G protein-coupled receptors (GPCRs) are important regulators of endocrine physiology, and peptide-based therapeutics targeting some of these receptors have proven effective at treating disorders such as hypercalcemia, osteoporosis, and type 2 diabetes mellitus (T2DM)

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