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Furthermore, systemic administration of bupropion increases the selection of the high-effort, high-reward option in a PR-choice task in rats (Randall, Lee, Podurgiel, et al

Given its small molecular weight, -Arbutin, with its hydroxyphenyl head, can easily fit into the binding pocket of both hTYR and mTYR

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Not only does it make them less bioavailable, but they often come with gastrointestinal side effects such as stomach pain, diarrhea and vomiting