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Studies have confirmed that the inhibition of S1R strengthen the anticancer effects of sorafenib in HCC cells in vitro and in vivo by inhibiting the expression of GPX4 (Ren et al., 2021)

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(2015) have shown that patients with T2D had a reduced risk of developing glaucoma when exposed to antihyperglycemic agents, in particular metformin, which was associated with a reduced risk of developing open-angle glaucoma