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Cannabidiol regulates the expression of keratinocyte proteins involved in the inflammation process through transcriptional regulation

No human evidence confirms this risk, but the mechanism warrants awareness

Based on our reviews findings, further research such as dose-optimization, long-term exposures, and delivery methods on human studies should be performed

Copper is classified as a weak sensitizer far weaker than nickel and frank copper contact allergy is documented but uncommon

This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings