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While this can occur due to estrogen changes associated with rapid weight loss, the case report above showed it occurring even with normal estrogen levels, suggesting a neurovascular mechanism related to GLP-1 receptor activity

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Women using oral contraceptives should use a backup method for 4 weeks after initiating tirzepatide and after each dose increase

Instruct patients to inform their doctor that they are taking JANUMET prior to any surgical or radiological procedure, as temporary discontinuation may be required [see Warnings and Precautions (5.1)]

A Phase 2 trial was conducted by Diagen (Croatia) for the treatment of ulcerative colitis