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This hypothesis is supported by Seahorse analysis, which revealed that CI inhibition by Rot treatment significantly reduced basal respiration, ATP-linked respiration, maximal respiration, and spare respiratory capacity, but not proton leak (Fig

Tiwari et al., 2015b)

Horm Metab Res (1995) 27(8):3725

Favorable results from cardiovascular outcome trials, demonstrating significant major adverse cardiovascular events (MACE) reduction, have been crucial