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Uncontrollable necrosis has been considered an ACD [60]

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This includes the crucial task of identifying specific populations that may derive the greatest benefit from hormetic interventions, both for disease prevention in at-risk individuals (such as those with metabolic syndrome) and as an adjunct therapeutic strategy for managing established chronic diseases, and subsequently developing effective strategies to promote the consumption of foods naturally rich in hormetic compounds

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Clinical constipation is defined as fewer than 3 bowel movements per week, often accompanied by hard stools requiring excessive straining and incomplete evacuation feeling