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MC1R is a G-protein-coupled receptor (GPCR) that, upon agonist engagement, activates the Gs/adenylate cyclase pathway, increasing intracellular cAMP and activating PKA-linked signalling cascades that upregulate tyrosinase activity and drive eumelanin synthesis the dark, UV-protective form of melanin

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Tau pathology is significantly correlated with the advancement of Alzheimer's disease and associated risk factors such as ApoE4 and TREM2 (8, 9)

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