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The FDA-approved indications focus on glycemic control in type 2 diabetes and chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity, with some products (Wegovy, Saxenda) also approved for certain adolescents

While the exact mechanism is not fully understood, researchers suggest the reproductive benefits from GLP-1 drugs may be driven by improvements in metabolic health

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It is believed that less incorporation of fatty acid substrates into sterols and glycerol-lipids affects the fluidity of the neuronal cell membrane and leads to an increase in the action potential threshold, which may contribute to the antiepileptic effect of valproates [58]

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