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Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus

In general, U.S

Glutathione metabolism is impaired when not protected, and systemic effect remains low

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

The enhanced efficacy profile potentially reduces treatment duration and improves patient compliance, translating to better therapeutic value propositions