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The evidence is diverse and includes extensive work with laboratory animals, otherwise unexplained associations, factors associated with APAP metabolism, and limited studies in humans

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An 8-week randomized double-blind trial compared GHK-Cu in a nano-lipid carrier against Matrixyl 3000 and found a 55.8% reduction in wrinkle volume versus control serum, along with a 32.8% reduction in wrinkle depth