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However, these results should be considered exploratory and require validation in larger, independent, age-matched, and longitudinal cohorts before clinical application

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Coverage denials are common when the indication is weight loss alone rather than diabetes

doi: 10.1021/la902266x

Ethylmalonic aciduria secondary to ETHE1 dysfunction (OMIM# 602473) Ethylmalonic encephalopathy (EE) is a rare, devastating, invariably fatal neurodegenerative disease caused by mutations in the ETHE1 gene, which encodes a mitochondrial sulfur dioxygenase critical in hydrogen sulfide (H 2 S) detoxification [147]