The researchers identified the PI3K/AKT signaling pathway as a key mechanism mediating Dihexa's cognitive benefits, expanding the mechanistic understanding beyond the original HGF/c-Met focus
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It binds to cell surface receptors and activates intracellular signaling cascades that upregulate collagen I, collagen III, and fibronectin production
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Concurrent evaluation of both peptides allows researchers to examine how cAMP-driven and calcium-dependent signaling pathways operate simultaneously within pituitary somatotrophs, providing a controlled model for studying pathway integration, receptor cross-communication, and endocrine signal coordination
